Case definition of PIMS-TS

Clinical 

Children and adolescents (up to 18 years of age) with fever ≥3 days 

AND two of the following:

  • rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet)
  • age-specific hypotension or “shock” within first 24 hours of presentation
  • features of myocardial dysfunction, pericarditis, valvulitis or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP)
  • evidence of coagulopathy (by PT, PTT, elevated d-Dimers)
  • acute gastrointestinal problems (diarrhoea, vomiting or abdominal pain).

AND elevated markers of inflammation such as ESR, C-reactive protein or procalcitonin.

AND exclusion of other infectious causes of inflammation, including bacterial sepsis, staphylococcal or streptococcal toxic shock syndromes.

Laboratory 

AND evidence of SARS-CoV-2 infection (positive RT-PCR), or confirmed contact with a person with SARS-CoV-2 infection (public health defined), or confirmed positive SARS-CoV-2 serology (noting testing may be delayed, particularly serology. If all other criteria are met, collect data pending results).

Clinical advice statement on PIMS-TS

A clinical advice statement on PIMS-TS has been developed by PAEDS and endorsed by the Royal Australasian College of Physicians (RACP). Access the statement here.

Read more about PAEDS work here.

 

 

 

Last updated December 2020